Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine

A review on precision medicine and conducting pharmacogenetics tests of drugs

Precision medicine, the selection of treatment based on the genetic characteristics of patients, is one of the new paradigms of medical science. Using genetic characteristics and biomarkers, patients' response to different treatments is evaluated and finally, a specific one is selected for them. In other words, using genetic information or biomarkers, the safety, effectiveness and outcomes of t...

precision medicine for endocrinology

Custom v. Standardized Risk Models

We discuss when and why custom multi-factor risk models are warranted and give source code for computing some risk factors. Pension/mutual funds do not require customization but standardization. However, using standardized risk models in quant trading with much shorter holding horizons is suboptimal: (1) longer horizon risk factors (value, growth, etc.) increase noise trades and trading costs; ...

Cervical Evaluation: From Ancient Medicine to Precision Medicine.

Since ancient times, cervical assessment for predicting timing of delivery has relied primarily on digital (subjective) assessment of dilatation, softening, and length. To date, transvaginal ultrasound cervical length is the only one of these parameters that meets criteria for a biomarker; no objective, quantitative measure of cervical dilatation or softening has gained clinical acceptance. Thi...

Fundamental Parameters from Precision Tests

I review how electroweak precision observables can be used to constrain the Higgs boson mass and the strong coupling constant. Implications for physics beyond the Standard Model are also addressed.